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Studies have shown that it can lead to significant weight reduction in people who are overweight or have obesity

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(6.1) The most common adverse reactions (incidence 20%) of pemetrexed when administered in combination with pembrolizumab and platinum chemotherapy are fatigue/asthenia, nausea, constipation, diarrhea, decreased appetite, rash, vomiting, cough, dyspnea, and pyrexia

Liu J, Wang L, Zhang A, Di W, Zhang X, Wu L, et al

TCA may itch a little, but it isnt painful at all