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Future strategies should therefore aim to fine-tune, rather than simply amplify, the oxidative resilience of engineered immune cells

The activity of mTORC1 is primarily mediated by phosphatidylinositol-3-OH kinase/RAC- serine/threonine-protein kinase/tuberous sclerosis complex (PI3K/AKT/TSC) and liver kinase B1/the mitogen-activated protein kinase (LKB1/AMPK) axis

Pregnant or breastfeeding women, and individuals with medical conditions or on medication, should consult a healthcare professional before use

Over time, this signaling cascade leads to impaired antitumor T cell function, fostering an environment conducive to tumor growth [109]

35 (2), e202000203 (2020)