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Low ATP or mitochondrial stress Converting methionine to SAM requires ATP

A genetic model for in vivo proximity labelling of the mammalian secretome

& Specker, J

33 , 62876295, doi:10.1093/nar/gki939 (2005)

In particular, the melatonin peak is associated with the nadir in body temperature, together with maximum tiredness, lowest alertness and performance (59) (Figure 6)