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In anti-inflammatory and anti-fibrotic approaches, novel nonsteroidal mineralocorticoid receptor antagonists such as finerenone inhibit the TGF-/Smad3 pathway, alleviating renal interstitial inflammation and collagen deposition ( Multi-target traditional Chinese medicine interventions also demonstrate promise, such as Huangkui capsule (containing quercetin and kaempferol as primary active components), which regulates the PI3K/Akt and AGE-RAGE signaling pathways while improving insulin resistance, inhibiting lipid accumulation, and suppressing NF-B-mediated inflammation (Niu et al., 2022

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Anti-inflammatory and Tissue Effects Beyond metabolic effects, semaglutide appears to modulate inflammation

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Oxygenation as phase I biotransformation, including hydroxylation (+ 3.8 1.4 2 ) and N-oxidation (+ 3.4 3.3 2 ), also perfectly fitted into the almost linear relationship (Fig