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In summary, although current studies suggest that ferroptosis plays a central regulatory role in the pathological sequence of PVLlinking hypoxiaischemia, inflammatory infiltration, and white-matter necrosisand provides a new mechanistic basis for understanding the pathway from periventricular iron accumulation to oligodendrocyte loss and motor developmental impairment, several essential gaps remain

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CB-839 is a small-molecule glutaminase-1 (GLS-1) inhibitor that impairs glutamine use, disrupts downstream energy metabolism, and impedes the elimination of reactive oxygen species

DAgostino, J

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