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It is thought that magnesium can interact with GABA receptors.[ref] A lot of people are low in magnesium, especially as they age

Jorn Schneider H, Klotsche J, Saller B et al (2008) Associations of age-dependent IGF-I SDS with cardiovascular diseases and risk conditions: cross-sectional study in 6773 primary care patients

Increased reactive oxygen species (ROS) Dysfunctional mitochondria produce excessive ROS, which can damage mitochondrial DNA, proteins, and lipids, exacerbating mitochondrial impairment and triggering pro-inflammatory signaling (Vicente-Gutierrez et al., 2019