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However, the pro-regenerative role of the mTORC1/S6K signaling pathway overwhelms the antiproliferative role of the p53/p21 signaling pathway in Wip1 deficient mice

PubMed PMID: 34380875 Sikiric et al

A probe with a 25 mm 25 mm surface was placed on the plantar surface of the left hind foot to measure the sensory threshold, and heat stimuli (Intercross-210, Intercross Inc., Tokyo, Japan) were applied to the plantar surface, with the rat in a prone position

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Both the innate and adaptive responses have a central role in the chronic tissue injury and epithelial damage that represent SLE (89, 90)