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Ipamorelin is a pentapeptide (five amino acids), developed later with a deliberate design goal: maximize GH selectivity while minimizing off-target hormonal effects

Radaelli E, Ceruti R, Patton V, Russo M, Degrassi A, Croci V, Caprera F, Stortini G, Scanziani E, Pesenti E, et al

However, a notable side effect was observed: MT-II-treated normal C57BL/6J mice exhibited significant weight loss, with their average weight decreasing from a baseline of 30.9 1.4 grams to 26.5 1.7 grams after the 14-day treatment course, a change not seen in vehicle-treated controls

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It has been reported that concentrations of 2.3 to 72.5 mg/dL to cause glomerular damage [22]