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10.1161/atvbaha.121.316495 74 ZhaoB.YangX.LiW.ZhuH.MengQ.MaY.et al (2023)

Instead, the researchers found that one of its metabolic breakdown productsthe smaller fragment Ac-LKKTEwas responsible for the biological activity, suggesting that the entire pharmacological understanding of how TB-500 operates may be flawed or incomplete