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2c, d and Supplementary Fig

10.1039/d0fo01805h Food Funct

discovered that the direct interaction between SMG9 and GPX4 protein leads to the degradation of GPX4 through a small-scale RNAi screening, thereby facilitating tumor suppression via ferroptosis [62]

Santa Cruz Biotechnology, Inc.), and anti--actin (Sigma), respectively

An initial sample of 30 million cells was harvested and infected cells were cultured for ~14 population doublings in either standard cell culture conditions or treated with 20M BSO