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5 CHAC1 involvement in non-malignant diseases Oxidative stress, resulting from the excessive accumulation of ROS and reactive nitrogen species (RNS), plays a critical role in the pathogenesis of various non-malignant diseases

Pure metabolic shift

Furthermore, GGCT deletion significantly induced ROS production and inhibited GSH levels

The link between SARS-CoV-2 and Parkinsons disease PD COVID-19 can exacerbate PD symptoms, which indicates the neurotropic nature of COVID-19 infection, either directly by virus tropism and host neuronal cell lysis in the basal ganglia as well as indirectly via microglia activation, increased proinflammatory mediators production, with vascular injury in the stressful hypoxic brain [108]