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It is suggested that Gq protein activation induces PLC/PIP 2 hydrolysis and generates IP 3 and DAG, which stimulate TRPC and increase intracellular Ca 2+ in response to light stimulation (Contreras et al., 2021

One possible criticism of this study or that while what we are observing with yeast may not be true, in case of mammalian cells response could be different and one might be experiencing oxidative stress response in the mammalian system, though not the yeast model

Phospholipase C - Manual Phospholipase C (originally called lecithinase and also referred to as -toxin) catalyzes the hydrolysis of the linkage between glycerol and phosphate in lecithin and other phosphatides

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96 Of note, GTPSCS functions as a lactyl-CoA synthetase in the nucleus and interacts with p300 to form a histone lactyltransferase complex to synergistically modulate H3K18la in this process