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Neurometabolites were quantified with LCModel [48], with prior reported chemical shifts and coupling constants [49, 50] as a basis for the model spectra of aspartate (Asp), ascorbate/vitamin C (Asc), glycerophosphocholine (GPC), phosphocholine (PC), creatine (Cr), phosphocreatine (PCr), -amino-butyric acid (GABA), glucose (Glc), glutamine (Gln), glutamate (Glu), glutathione (GSH), myo-inositol (myo-Ins), N-acetylaspartate (NAA), N-acetylaspartylglutamate (NAAG), phosphoethanolamine (PE), scyllo-inositol (scyllo-Ins) and taurine (Tau) were generated based on previously reported chemical shifts and coupling constants.by using GAMMA/PyGAMMA simulation library of VESPA for applying the density matrix formalism (Versatile Simulation, Pulses and Analysis 9)

In contrast, feeding markedly alters plasma acylcarnitine levels

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Moreover, the presence of diminished muscle mass and power, aberrant muscle quality characterized by increased fat or myosteatosis, electrolyte imbalances, malnutrition, subclinical myopathy, diminished motivation, memory, and concentration, alongside an array of mental health and sleep disorders directly linked to or associated with the underlying disease, further exacerbate, and contribute to fatigue in cirrhosis (9)

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