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Inflammatory chemicals flood the damaged tissue, triggering pain receptors

Similarly, impeding the CYFIP1/Rac1 interaction or the CYFIP1/NCKAP1 dimer formation, could have a dual beneficial effect in concomitantly restoring normal levels of protein synthesis and actin dynamics, both processes being dysregulated in FXS

Synthetic fresh urine (SU 1 -SU 4 ) that mimicked the composition of real fresh urine was prepared by dissolving urea and inorganic compounds (NaCl, Na 2 SO 4 , KCl, MgCl 2 .6H 2 O, NaH 2 PO 4 , CaCl 2 , and NH 4 Cl) in Milli-Q water and adjusting the pH of the solution with NaOH (Table 1)

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