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10 Overall, current research predominantly concentrates on L-lactylation, with limited revelation of non-enzymatic lysine D-lactylation, whose mechanism remains ambiguous and needs further investigation

ABCB7 also provides direct contacts with the substrate the conserved F426 aromatic pair form hydrophobic and van der Waals interactions with the bound CoPP (Fig

Most patients require 2-3 treatments spaced about 2-3 weeks apart to achieve optimal results

doi: 10.1038/s41586-020-2857-9 41 Moreira FrancoYEAlvesMJUnoMMorettiIFTrombetta-LimaMde Siqueira SantosSet al

doi: 10.1038/nature20791 279 Martinez-OutschoornUELinZWhitaker-MenezesDHowellALisantiMPSotgiaF