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IGF-1 metabolic actions are partly directed at stimulating the uptake of glucose, fatty acids, and amino acids so that metabolism supports growing tissues

This mechanism may be primarily caused by the deregulation of the Ca 2+ homeostasis induced by the mutation in PSEN1 , as described in PSEN1 mutant AD iPSC-derived astrocytes (Oksanen et al., 2017)

showed that CPT II activity is decreased in the liver mitochondria of tumor-bearing cachectic rats [33]

[PubMed: 6500232] Hall LN, Sanchez LR, Hubbard J, Lee H, Looby SE, Srinivasa S, et al

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