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Moreover, astrocytes trigger neurogenesis by releasing neurogenesis-related factors such as Wnt3, insulin-like growth factor binding protein 6, interleukin 1 and interleukin 6

By comparison, HMO6, a v-mycimmortalized embryonic microglial line, retains several microglial markers and phagocytic activity, but provides a markedly attenuated inflammatory cytokine response compared to primary cells, limiting its suitability for detailed immune functional studies (148, 163)