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Cytoplasmic protein aggregates, a pathological feature of ALS, disrupt key cellular degradation mechanisms, including both the ubiquitin-proteasome system and autophagy pathways, resulting in catastrophic failure of protein homeostasis

Common genetic variants in detoxification and response genes such as CYP1A2, CYP3A4, GSTM1, GSTA1, GSTP1, UGT1A1, XPC, GSDMB, and IL13 can increase susceptibility to mitochondrial damage, organ injury, or asthma from mycotoxins

Given that there is no evidence of sex-dependent susceptibility to ISKNV in mandarin fish, fish were randomly assigned to groups regardless of sex

Zhang K, Zhu S, Li J, Jiang T, Feng L, Pei J, et al

Among all three variants, Keep It Chill offers the strongest sweat protection