b12 injection subcutaneous or im Treating Severe Vitamin Deficiency B12 vitamin Store Intramuscular vs

Ongoing B12 injections, generally for life, are required for those with PA

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We understand that a variety of factors can affect the duration of the Vitamin B12 shots efficacy

To-date, we have data to support longevity for a few years and will continue to monitor how many years patients can expect to see the substantial improvement

Extracellular NAD + independent of ATP and cGAMP ( Figure 1 + to ADPR, AMP, and ADO, respectively, bypassing ATP- and cGAMP-dependent routes ( + -dependent pathway is highly active in the hypoxic and acidic BM niche, favoring ADO accumulation