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Melatonin is reported in numerous studies to effectively inhibit EMT in tumorigenesis by targeting vimentin ( -synuclein and A in both in vitro and in vivo experimental conditions ( During aging, mitochondrial dysfunction results in a vicious cycle wherein increased ROS production and decreased ATP levels result in aberrant phase separation of an extensive array of mitochondrial physiological processes (Figure 5), but is protective for AD, while APOE4 (two arginine moieties, no cysteine) is protective in AMD, but is a strong risk factor for AD ( RPE cells are dependent upon mitochondrial OXPHOS to maximize energy production, suppressing glucose consumption to ensure adequate supply to the retina ( - stacking and van der Waals interactions ( 6 Melatonin as an antioxidant and anti-inflammatory agent Melatonin has a host of cytoprotective actions which alter the course of AMD