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*Correspondence: Yulong Yin, [email protected] Deng, [email protected] These authors have contributed equally to this work This article was submitted to Microorganisms in Vertebrate Digestive Systems, a section of the journal Frontiers in Microbiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

These include diabetes or high blood pressure that is not well managed anticoagulation or bleeding disorder allergies or hypersensitivity to steroid medication or anesthesia infection at the site of the injection congestive heart failure While doctors consider spinal injections generally safe, severe complications may occur in rare cases

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While the medulla is hyperosmolar to concentrate urine, its restricted blood supply results in a naturally hypoxic state

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