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In acquired B12 deficiency, both oral and IM routes have been featured in guidelines to replenish this compound in deficient states

It is most relevant during GLP-1 use or caloric deficit, when fatigue is part of the picture, with age-related NAD+ decline, or when progress stalls after a clean first month

[DOI] [PubMed] [Google Scholar] 20.Trammell SAJ, et al