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Remarkably, R4VPL3-1 was potent towards primary untreated patient-derived sarcoma and lung tumor cells isolated during onco-surgical resections, inhibiting proliferation and sphere formation in culture with IC 50 ~ 0.5M of multiple sarcoma entities (Fig

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Furthermore, oxidative stress impairs the antioxidant defense system by decreasing expression of key enzymes such as GSH, catalase, superoxide dismutase and GPX, thus accelerating ferroptosis (56,57)

To advance translational applications, future research should focus on: (1) Elucidating interactions between engineered bacteria and the gut microbiota to identify inflammation-related regulatory targets