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TP73 as novel determinant of resistance to BCL-2 inhibition in acute myeloid leukemia

While studying human lung cells, the Salk team discovered that elevated levels of the enzyme acid ceramidase make senescent cells more susceptible to ferroptosis and can pass that vulnerability to neighboring cells

We chose NRAS over BRAF because there is more frequent CDH1 downregulation in NRAS -mutant melanomas and a lack of targeted therapies for NRAS -mutated cases (Extended Data Fig

EC50 refers to the concentration of an antibody or an antigen-binding portion thereof or an immunoconjugate described herein, that induces a response, either in an in vitro or an in vivo assay, which is 50% of the maximal response, i.e., halfway between the maximal response and the baseline

This makes glutathione work extra hard, using it up faster than it can be replaced