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doi: 10.3389/fnut.2023.1120377 Received 09 December 2022 Accepted 31 January 2023 Published 16 February 2023 Volume 10 - 2023 Edited by Monika Thakur, Amity University, India Reviewed by Abdul Rehman Phull, Shah Abdul Latif University, Pakistan

This allows these toxins to get back into the bloodstream, where they can cause problems such as estrogen dominance disorders (8)

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Tumor necrosis factor-alpha (TNF-alpha), a cytokine involved in systemic inflammation, along with matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) enzymes that break down extracellular matrix proteins might potentially influence both the inflammatory processes and the remodeling of tissues

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