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A glutathione deficiency therefore leads to the activation of von Willebrand factor and the accumulation of ROS, which affect coagulation and platelet activation , impair endothelial function and predispose to the risk of thrombotic events , in particular hypercoagulation

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The oxidative stress results from an imbalance of pro-oxidant/antioxidant homeostasis that leads to an abnormal production of reactive oxygen species (ROS)

Moreover, previous studies have demonstrated that AP-associated multi-organ dysfunction (e.g., lung, kidney, liver) can be improved by TCM prescription treatment, such as Dachengqi decoction (Liu et al., 2023), Yinchenhao decoction (Zhao et al., 2024), and Chaiqin Chengqi decoction (Yang X

This mirrors findings in mammals where Hs PP5 dephosphorylates various kinases, such as SAPKs and apoptosis signal-regulating kinase 1 (ASK1), which are involved in apoptosis and stress responses 40