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This cysteine-homocysteinylation event perturbs the pro-insulin receptor and furin protease interaction within the Golgi apparatus, consequently inhibiting the cleavage of the pro-insulin receptor

However, not everyone absorbs vitamin B12 efficiently

It can lead to neuropathy, megaloblastic anemia, and pernicious anemia, [2] [13] causing symptoms including fatigue, paresthesia, depression, cognitive decline, ataxia, and even irreversible nerve damage

showed a correlation between lower B12 levels and a lower age at MS onset

The commensal bacteria residing in the intestinal lumen significantly influence the mammalian NAD + metabolism