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Metabolic Dysfunction in the Regulation of the NLRP3 Inflammasome Activation: A Potential Target for Diabetic Nephropathy

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In recent decades, the following treatments for IC/BPS have been recommended as replenishment of the glycosaminoglycan layer to control urothelial defects, administration of amitriptyline or imipramine to inhibit neurological hyperactivity, suppression of allergies by antihistamines, and non-steroid anti-inflammatory drugs for pain control ( Intravesical treatments with heparin, hyaluronic acid, chondroitin sulfate, bacillus Calmette-Guerin, dimethylsulfoxide, and resiniferatoxin have been effective in treating IC/BPS, but the effects were not durable ( Despite the availability of multiple treatment options, which offer a wide range of possible combinations and a high level of personalization, identifying the optimal treatment for complex diseases remains challenging

doi: 10.1111/j.1440-1754.1997.tb01578.x

Look for "copper tripeptide-1" in the INCI ingredient list, ideally in the top half of the list