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Description

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Sensorgrams were analyzed using a global fit to the 1:1 Langmuir binding model

Voiding frequency is almost universal (92% of one population), 46 but does not distinguish the IC/BPS patient from other lower urinary tract disorders

SNX-0723, identified through scaffold-based screening, selectively binds the ATP-binding pocket of HSP90 and demonstrates improved brain penetration, reducing mutant huntingtin aggregation in PD and HD models