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Its the baseline

Among them, HMGB1 expression was notably elevated in tumor samples compared to healthy controls, suggesting its role in tumorigenesis and ferroptosis resistance

Misplaced iron in kwashiorkor

Oxidative damage to lipids, amino acids, and proteins impairs mitochondrial function, triggering a vicious cycle of ROS generation and cellular damage (42)

Cuproptosis provides new evidence that metal-induced cell death is not solely dependent on oxidative stress, and its close relationship with mitochondria gives us a further understanding of the role of mitochondrial quality control in cell death