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The future role and position of insulins in the T2D treatment continuum will need to be reconsidered, given incretin-based therapies provide substantial reduction in HbA1c without the potential for weight gain and hypoglycaemia seen with insulins

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10.3389/fphar.2020.617843 165 YangW.ZhangJ.XuB.HeY.LiuW.LiJ.et al (2020)

Recent studies concluded that the abnormal cerebellar development, due to a variety of causes, including abnormal regional expression of TSC1 , TSC2 genes , and related gene networks, may contribute to cognitive and neuropsychiatric disorders such as ASD [21]

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