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In in vitro experiments, Pepaxto was 50 times more potent in killing multiple myeloma cells than the alkylating agent it carried due to its ability to increase the intracellular concentration of the alkylating agent

1 Nutrition [9] [10] This latter form of folate is thought to be more effective than standard folic acid

It works to reduce side effects like nausea and inflammation while supporting the body's defenses

The researchers induced diabetes observed in iron deficiency (HFE) knockout mice, a genetic representation of iron overload

Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition