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Furthermore, iron-mediated epithelial cell death promotes the secretion of various pro-fibrotic factors such as TGF-, CTGF, etc., inducing proliferation and differentiation of interstitial fibroblasts, ultimately leading to renal fibrosis

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Consistently, the mRNA expressions of Ctgf , Tgfb1 , Acta2 , Col1a1 , and Col3a1 were elevated in the DKD group, but significantly decreased after HU treatment (Figures 2CG)