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N-acetylcysteine (NAC) is effective both in inhibiting biofilm formation and in destroying developed biofilms

Primary Handling Editor: Jean Nakhle, in collaboration with the Nature Metabolism team

The best binding was observed for the histidine containing peptide as expected, whereas slightly weaker affinity was observed for amide (Q, N) or amine (K) containing side chain, whereas carboxy (D,E), thioether (M) or aromatic (F,Y,W) functional groups hardly enhanced affinity compared to the single histidine containing peptide (Fig

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