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First, although SLC30A10 mediates the release of Mn from the brain and SLC39A8 facilitates its uptake 312 , the precise mechanisms that regulate neuronal Mn transport and accumulation remain poorly understood

Cells 38 (4), 327335

doi: 10.3892/etm.2025.12821 [DOI] [PMC free article] [PubMed] [Google Scholar] 145.Zhang W, Ren H, Chen W, et al

This led to GSH depletion, a burst of lipid peroxides, and accumulation of labile iron, collectively triggering ferroptosis

In glaucoma, the increased levels of A, p-tau, and amyloid precursor protein initiate an inflammatory response, leading to cytokine secretion and iron overload