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This guidance reflects a more precautionary stance and provides industry with a clearer roadmap on the data needed for nano-scale ingredients

10.1007/978-88-470-2215-7_19 Proceedings of the 17th Postgraduate Course in Critical Care Medicine 39 FreoU.OriC

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The activity of GPCRs or homologues thereof, can be measured using any assay suitable for the measurement of the activity of a G protein-coupled receptor, as commonly known in the art

In comparison to the WT, assays evaluating interactions with HD11 chicken macrophages revealed a substantial impairment in the adhesion and invasion capabilities of the GR mutant strain (Figures 1F and G)