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CRLs utilize a cullin protein backbone, which simultaneously binds to both an E2 ubiquitin conjugating enzyme and substrate, positioning E2 and substrate in close proximity, and enabling the rapid transfer of ubiquitin onto substrates (Figure 1A)

Our findings suggest melatonin can regulate copper and iron homeostasis and protect against cuproptosis and ferroptosis in aging ovarian cells

However, the anti-inflammatory and/or protective roles of cytokines, including IL-4, IL-10, IL-19 and IL-22, have been shown in the existing literature, especially in the pathogenesis of cardiovascular diseases (Haybar et al

2023;56:e13335