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The desensitisation procedure should be started by the 1/1001/1000 solutions of the drug target or the 1/101/1000 solutions of positive intradermal test dose and in increasing doses by doubling with 3090min intervals until the therapeutic dose is achieved.5 Desensitisation must be carried out in a hospital setting by experienced personnel with adequate resuscitation equipment readily available

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Although initial studies indicate that treatments such as iron chelators and lipid peroxidation inhibitors may have cardioprotective effects, their long-term efficacy and safety profiles have not been comprehensively evaluated in clinical trials, leaving significant room for further investigation (Yang T

10.18632/aging.203701 81 HadannyA.Daniel-KotovskyM.SuzinG.Boussi-GrossR.CatalognaM.DaganK.et al (2020)