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Yet chronic HIF activation, as observed in prolonged anemia or systemic hypoxia, contributes to inflammatory signaling, tissue remodeling, and mitochondrial dysfunction, accelerating cellular senescence and organ aging [39]

10.1016/j.theriogenology.2021.11.013 13

Roxas VP, Smith RK, Allen ER, Allen RD: Overexpression of glutathione S -transferase/glutathione peroxidase enhances the growth of transgenic tobacco seedlings during stress