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By linking epithelial drug-metabolizing expression, transporter expression, microbial xenobiotic pathway, biomechanical cues, and measured metabolite profiles to parent-drug depletion, these models could identify whether a change in per-oral bioavailability is driven primarily by host epithelial metabolism, microbial biotransformation, or microenvironmental conditions

meliloti , or R

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doi:10.1080/09513590.2020.1843619

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