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Apart from female and male infertility (41, 42), Se deficiency was connected to heart disease (possibly fatal congestive dilated cardiomyopathy, including endemic Keshan disease), musculoskeletal and neuromuscular disorders (e.g., KashinBeck disease), thyroid function dysfunction, disrupted immune function, poor response to acute and chronic infections (including COVID-19, Coxsackie, influenza, and HIV viral infections), chronic inflammation, cancer (including colonic, gastric, pulmonary, and prostate carcinoma), and other disorders (40, 4348)

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