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At the time when SOD and catalase were identified in joints and shown to protect synovial fluid degradation by ROS during inflammatory processes, therapeutic approaches against OS were suggested (McCord 1974)

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A more evidence-based approach for skin during weight loss combines topical GHK-Cu (cheap and reasonably supported), adequate protein intake (1.2 to 1.6 g/kg body weight), resistance training, sufficient hydration, and patience for natural skin remodeling

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Proc R Soc Lond B 270:23832388 Wilcoxen TE, Horn DJ, Hogan BM, Hubble CN, Huber SJ, Flamm J, Knott M, Lundstrom L, Salik F, Wassenhove SJ, Wrobel ER (2015) Effects of bird-feeding activities on the health of wild birds