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Int J Mol Sci 21(22)

In the Sprague-Dawley rat model, PTER improves cholinergic transmission due to the decrease in the activity of acetylcholinesterase and increases the action of ATPases (Na + , K + , Ca 2+ , and Mg 2+ ), which is indicative of the maintenance of the cell membrane potential (Naik et al., 2017)

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More specifically, oral administration is safer than intramuscular injection in animal models because artemisinin is present in experimental animals for a long period after its slow release from intramuscular formulations, leading to severe side effects (Gordi and Lepist, 2004)