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Pflugers Arch 466:18591872

With this procedure, the incision site can be further away from the affected area, which can be advantageous in cases where local tissue damage prevents surgical access

however, it remains unknown how the metabolic microenvironment in healthy or disease-affected organs affects ROS production in vivo and, consequently, T-cell activation and differentiation

Hu and Z

The authors use this rationale cautiously to reconcile the mismatch between improved cognition and reduced brain volume, stating A clearance and subsequent shifts in cerebrospinal fluid may therefore have also partially explained their findings