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The investigations of the present study revealed diminished Nrf2 and HO-1 expression in HG-induced HK-2 cells in vitro and in an in vivo DN model

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CKD causes endothelial dysfunction by reducing NO production and increasing oxidative stress, which impairs vasodilation and blood flow to penile tissue [136]

TLK286 showed interesting in vitro and in vivo antiproliferative activity on cells with high GST P1-1 expression as a result of selection for doxorubicin, cyclophosphamide, and platinum resistance (Morgan et al., 1998