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Collectively, these associations reinforce the role of both ingestion and inhalation as dominant exposure pathways, with oxidative and genotoxic mechanisms serving as central drivers of malignancy

Suitable candidates often include middle-aged adults, especially women, and individuals who are overweight or engage in prolonged standing or high-impact activities

Unless there is clear evidence of primary bladder pathology (e.g., small capacity under anesthesia, Hunner lesions), patients should have a multidisciplinary evaluation including assessment for neuropathic pain and psychological profile

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Front Pharmacol 14:1205207