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Studies show that they increase EAAT2 expression.[ref] Natural substances that increase glutamate transporters: Harmine , which is a naturally occurring alkaloid found in Syrian rue and ayahuasca, increases EAAT2 expression and thus decreases glutamate excitotoxicity

The exploration of the association between miR-503-5p and WNT3A Using TargetScan, this study predicted the potential binding sites between miR-503-5p and WNT3A mRNA

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However, this clinical trial had a limited sample size (placebo: 23 patients, riluzole: 25 patients), which means that further large-scale clinical studies are needed to clarify the effect of riluzole

Surprisingly, we discovered that Hnf4 exhibited strong binding to its own promoter area using the JASPER tool prediction