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ARS-853 was developed from first-generation compounds 6 and 12 by optimising electrophilic localisation and modifying the scaffold that interacts with a hydrophobic portion of the S-IIP 120,121

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D4060) and cloned into the library vector using Golden Gate cloning with Esp3I (Thermo Fisher Scientific, catalogue no

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For instance, elevated GLUT3 expression is observed not only in thyroid cancer [33] and glioblastoma [34] but also across a range of aggressive tumors such as triple-negative breast cancer [35] and head and neck squamous cell carcinoma [36], where it is significantly associated with a poor prognosis for patients