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doi: 10.1016/j.jtemb.2004.03.004 256 WangHZhangJYuH

There is evidence that anxiety-like phenotypes may be related to melatonin deficiency, as treating 3xTg mice with melatonin not only ameliorates behavioral deficits but also downregulates the glutathione S-transferase P 1 (GSTP1) protein in the hippocampus (Nie et al., 2017)