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This is associated with an inflammatory phenotype and can promote neurodegeneration

Activation of Nrf2 and a subsequent induction of GCL have been reported for various oxidants and electrophiles such as DEM, H 2 O 2 , quinones, 4-hydroxynonenal, methyl mercury, arsenicals, and plasmonic gold nanoparticles (Zhang et al

Reducing glutathione production in lymphoma cells, either through pharmacological inhibition of glutamate cysteine ligase (GCL), the enzyme catalyzing the rate-limiting step in glutathione biosynthesis, or via knockdown of GCLC , the GCL catalytic subunit, sharply decreased cell growth in 3D gels and xenografts

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557 GPX4 is recognized as the principal regulator of ferroptosis since it can convert PLOOHs in the membrane into nontoxic alcohols